The Kimberling Usher Research Laboratory in the Institute for Vision Research is pleased to announce an increase in our campaign goal to $10 million. This increase is possible because addiitonal major donors have joined the "challenge side" of the matching effort so that we can now match every gift for Usher Syndrome Research, dollar for dollar, until $10 million is raised.
July 13th, 2018
January 31st, 2018
The University of Iowa has decided to return the name of our institute to The University of Iowa Institute for Vision Research.
You can read the full text of the University’s press release here.
I understand and support the University's decision.
December 27th, 2017
The pharmaceutical company Spark Therapeutics recently announced FDA approval1,2 of a gene therapy known as Luxturna, which has been shown to improve vision in patients with an extremely rare inherited eye disease caused by mutations in the gene RPE65. Scientists estimate this disease to occur in less than one in 500,000 people – or about 560 people total in the United States3,4.
The company has priced the drug at $425,000 per eye ($850,000 per patient), which does not include the cost of the surgery5.
November 30th, 2017
Scientists at the WIVR recently published a report in which they tested the efficiency and retinal cell type targeted by 7 different serotypes of adeno-associated virus (AAV) in the human retina. This paper is significant as most testing of AAVs is performed in animal models such as mice, rats, pigs and monkeys. In this report, WIVR investigators developed a protocol for culture of human donor retinas that allowed for the assessment of AAVs ex vivo.
October 24th, 2017
A new publication from the laboratory of Val Sheffield, M.D., Ph.D., focuses on the role of a specific protein complex found in photoreceptor cells and its role in retinal degeneration in a blinding disorder known as Bardet-Biedl syndrome (BBS). This protein complex is called the BBSome. Ying Hsu and Janelle Garrison, a graduate student and postdoctoral fellow respectively, who performed much of the work, demonstrated that the BBSome is indispensable for the initial formation and continued maintenance of the outer segment, the light sensing component of photoreceptor cells.
October 5th, 2017
July 18th, 2017
The RPE65 gene therapy study group at the Wynn Institute for Vision Research at the University of Iowa and The Center for Molecular and Children’s Hospital of Philadelphia published a paper in the journal, The Lancet, which showed the safety and effectiveness of voretigene naparvovec (the "new" name of AAV-RPE65 ) in a phase 3 FDA trial. This is an important milestone for gene therapy. As Dr. Stone recently published in the journal Ophthalmology, most inherited retinal degeneration genes will fit into the adeno-associated viral vector tested in this study.
Clinically Focused Molecular Investigation of 1000 Consecutive Families with Inherited Retinal DiseaseJune 1st, 2017
A team of WIVR investigators undertook the molecular investigation of 1000 consecutive families with inherited retinal disease. This study validated the clinically directed tiered testing strategy employed by the Carver Nonprofit Genetic Testing Laboratory at the University of Iowa, which increases sensitivity and improves statistical significance without increasing cost.
March 30th, 2017
A new WIVR study shows that high-resolution 3D-printing can be used to create protective scaffolds that also align patient-specific retinal precursor cells for delivery to the sub-retinal space.
March 18th, 2017
A team of WIVR researchers have developed patient-specific iPSCs, which will provide a platform for testing multiple treatments in patients suffering from TRNT1-associated RP. We previously identified novel hypomorphic mutations in the tRNA Nucleotidyl Transferase, CCA-Adding 1 (TRNT1) gene that cause early-onset RP. Mutations in TRNT1 caused reduced levels of full-length TRNT1 protein and a deficit in autophagy in both patient-specific iPSCs and iPSC-derived retinal organoids.